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Updated: May 26, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
tRNA intron-derived small regulatory RNAs fine-tune gene expression under oxidative stress
1Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China; New Cornerstone Science Laboratory, State Key Laboratory of Epigenetic Regulation and Intervention, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China.
Abstract:
The intron sequences of certain tRNAs are evolutionarily conserved among specific organisms, implying potential cellular functions of such tRNA introns. In this issue, Nostramo et al.1 identify free introns of tRNAs (fitRNAs) in S. cerevisiae as small regulatory RNAs that dynamically control mRNA levels in response to oxidative stress.
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