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Research Domains
Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Large-scale screens identify a 19-Gene MitoScore for improved risk assessment in acute myeloid leukemia

Large-scale screens identify a 19-Gene MitoScore for improved risk assessment in acute myeloid leukemia

Liting Niu ¹, Hanfei Guo ², Yijing Zhao ¹

Liting Niu ¹, Hanfei Guo ², Yijing Zhao ¹

¹Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
²The First Hospital of Jilin University, Cancer Center, Changchun, Jilin 133021, China.

⁰Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.

Mitochondrion +

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February 21, 2025

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February 21, 2025

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View abstract on PubMed

Summary

This summary is machine-generated.

A new 19-gene mitochondrial score (MitoScore) effectively predicts survival and chemotherapy resistance in acute myeloid leukemia (AML) patients. This biomarker refines risk stratification beyond current methods, aiding in tailored treatment decisions.

Area Of Science

Hematology
Molecular Biology
Genomics

Background

Acute myeloid leukemia (AML) is characterized by significant molecular and genetic heterogeneity.
Understanding AML pathogenesis and therapeutic resistance requires identifying key biological drivers.
Mitochondrial function assessment in AML is underemphasized, highlighting the need for mitochondrial biomarkers.

Purpose Of The Study

To identify AML-specific mitochondrial genes.
To develop and validate a prognostic mitochondrial score for AML patients.
To evaluate the score's utility in risk stratification and predicting treatment response.

Main Methods

Systematic integration and analysis of transcriptomics data from nine AML databases.
Screening of the Human.MitoCarta3.0 database for mitochondrial genes.
Development of a prognostic mitochondrial score (MitoScore) using LASSO regression in a training cohort and validation in independent cohorts.

Main Results

A 19-gene mitochondrial score (MitoScore) demonstrated high prognostic power in 2,315 AML patients.
MitoScore is an independent survival biomarker and significantly improves European Leukemia Net (ELN) classification.
High MitoScore correlates with poor response to induction chemotherapy and refractory AML, and distinguishes between genetic abnormality groups.

Conclusions

MitoScore serves as a robust biomarker for refined risk stratification in AML.
The MitoScore effectively predicts chemotherapy resistance in AML patients.
This tool can guide risk-adapted therapy decisions for improved clinical outcomes.

Keywords:

Acute myeloid leukemia Mitochondrial Prognostic model

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