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Related Experiment Video

Updated: May 26, 2025

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

Urinary concentrations of phthalate metabolites and the survival of high-grade serous ovarian cancer with advanced

Wen-Rui Zheng¹, Yi-Zi Li¹, Jin Xu²

¹Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China.

Environmental Pollution (Barking, Essex : 1987)

|February 21, 2025

Summary

This summary is machine-generated.

High phthalate exposure, especially di(2-ethylhexyl) phthalates, is linked to worse overall survival (OS) in advanced high-grade serous ovarian cancer (HGSOC) patients. Avoiding personal care products with these chemicals may improve outcomes for HGSOC survivors.

Keywords:

DEHP Endocrine disruptor Nested case-control study Overall survival

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Area of Science:

Environmental Health
Oncology
Toxicology

Background:

Phthalates are endocrine disruptors linked to hormone-dependent cancers.
Evidence on phthalate impact on overall survival (OS) in advanced high-grade serous ovarian cancer (HGSOC) is limited.

Purpose of the Study:

To investigate the association between urinary phthalate metabolites and OS in patients with advanced HGSOC.

Main Methods:

Nested case-control study within the Ovarian Cancer Follow-Up Study.
Matched 159 deceased HGSOC patients with 159 survivors.
Analyzed 10 phthalate metabolites and 5 phthalate molar sums in urine via mass spectrometry.
Used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs).

Main Results:

Higher levels of mono-2-ethyl-5-oxohexyl phthalates (OR=4.24) and monoethyl phthalates (OR=3.28) were associated with poorer OS.
Elevated sums of di(2-ethylhexyl) phthalate metabolites (OR=18.4), high-molar-weight phthalates (OR=9.28), and total phthalates (OR=5.94) correlated with worse OS.
Significant associations were observed when comparing the highest tertile of exposure to the lowest.

Conclusions:

High phthalate exposure, particularly di(2-ethylhexyl) phthalates, may be associated with poorer OS in advanced HGSOC patients.
Reducing exposure to phthalates, commonly found in personal care products, could potentially improve OS for HGSOC patients.