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Glial vascular Unit as a bridge between Blood-Brain Barrier and glymphatic System: Roles in sepsis-associated
Jiyun Hu1, Shucai Xie1, Tao Chen1
1Department of Critical Care Medicine, Hunan Provincial Clinical Research Center for Critical Care Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Abstract:
This article underscores the Glial Vascular Unit (GVU) 's possible role in bridging the Blood-Brain Barrier (BBB) and Glymphatic System in Sepsis-associated encephalopathy (SAE). Future studies should prioritize understanding the mechanistic underpinnings of GVU dysfunction in sepsis and explore interventions aimed at modulating BBB permeability, astrocytic function, and glymphatic clearance. Understanding these complex mechanisms is crucial for developing therapeutic strategies aimed at mitigating the neurological impact of sepsis and improving outcomes for patients with SAE.
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