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Updated: May 26, 2025

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Computational insights into fucoidan-receptor binding: Implications for fucoidan-based targeted drug delivery
Rumana Ferdushi1, Dohyeon Kim2, Dinesh Kumar Sriramulu3
1Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea.
Abstract:
Fucoidan, a polysaccharide from seaweed, holds promise as a drug delivery system and immune modulator; however, its exact mechanism of action remains unclear. As various carbohydrates play key roles in immune responses by binding to carbohydrate-binding proteins like lectins, fucoidan is hypothesized to interact with immune receptors, potentially driving its anticancer activities. However, structural variability, extraction-induced heterogeneity, and weak binding affinities pose challenges to research. Computational tools offer valuable insights into fucoidan-receptor interactions, addressing these challenges and enabling the design of more effective therapies. This review examines fucoidan's therapeutic activities, drug delivery potential, and receptor interactions, emphasizing computational approaches to advance immune modulation and anticancer applications using carbohydrate polymers.
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