Early vascular aging ambulatory score in acute ischemic stroke

Area of Science:

• Cardiovascular Research
• Neurology
• Gerontology

Background:

• Early vascular aging (EVA) impacts health outcomes, but its role in acute ischemic stroke (AIS) requires further elucidation.
• Prognostic assessment in AIS can be improved by identifying novel predictive markers.
• The EVA ambulatory score (EVAAs) is a potential tool for evaluating vascular health.

Purpose of the Study:

• To validate the EVA ambulatory score (EVAAs) in patients with acute ischemic stroke (AIS).
• To assess the association between EVAAs and stroke type, severity, and prognosis.
• To determine if EVAAs can predict adverse outcomes in AIS.

Main Methods:

• Retrospective analysis of 2,730 AIS patients.
• Validation of the EVA ambulatory score (EVAAs) for predicting outcomes.
• Subgroup analyses based on cardiovascular disease burden and lipid profile.

Main Results:

• A high prevalence of EVA (83.4%) was observed in the AIS cohort.
• EVA was an independent predictor of poor outcomes at discharge (aOR: 1.72) and 90 days (aOR: 2.22).
• EVAAs demonstrated enhanced predictive value in specific subgroups, including those with lower cardiovascular burden.

Conclusions:

• The EVA ambulatory score (EVAAs) is a significant predictor of adverse outcomes in AIS patients.
• EVAAs can be easily integrated into clinical practice for improved prognostic assessment.
• Identifying and managing EVA may offer new therapeutic avenues for AIS patients.