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Updated: May 26, 2025
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Neonatal pulmonary function tests in infants born to COVID-19 positive mothers
Katy Ruch1, Kelvin D MacDonald2, Kseniya Parkhotyuk1
1Division of Neonatology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Objective:
To compare pulmonary function tests (PFTs), specifically passive respiratory system compliance (Crs), in infants of mothers positive for COVID-19 during pregnancy compared to PFTs from a historical cohort of matched, healthy reference infants.
Study Design:
A prospective cohort study of infants born to COVID-19 positive mothers. Crs was measured with the single breath occlusion technique. Historical cohort data was obtained from a pre-COVID-19 data repository. Respiratory questionnaires were done at 1-year postnatal age.
Results:
Twenty-four PFTs in the COVID-19 cohort were compared with PFTs from 24 reference subjects. Infants of the COVID-19 positive mothers had a Crs of 3.57 ml/cmH2O versus 3.76 mL/cmH2O in the reference group (p > 0.05). The remaining PFT outcomes were comparable between groups. The COVID-19 infants reported more allergic symptoms and conditions through 1-year.
Conclusion:
We found no difference in Crs in infants of mothers with COVID-19 during pregnancy compared to a historical pre-COVID reference cohort.
