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Decoding host-microbe interactions with engineered human organoids

Lucas A Meirelles1,2, Alexandre Persat3,4

  • 1Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

The EMBO Journal
|February 21, 2025
PubMed
Abstract

No abstract available in PubMed .

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Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...