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Updated: May 26, 2025

Murine Dermal Fibroblast Isolation by FACS
Published on: January 7, 2016
The Role of Fibroblasts in Chronic Inflammatory and Proliferative Skin Diseases
Rui Zang1, Chen-Chen Xu1, Zhu Fan1
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Abstract:
Fibroblasts (FBs) are crucial mesenchymal cells that preserve the skin's natural structure and physiological processes. They can build dense connective tissue by remodelling the extracellular matrix (ECM) and control immunological activity by secreting cytokines. This indicates that the development of chronic inflammatory and proliferative skin disorders is significantly influenced by fibroblasts. In order to provide new ideas for clinical research and treatment with a clearer perspective, this study thoroughly compiles the involvement of fibroblasts in various chronic inflammatory and proliferative skin diseases such as psoriasis, hypertrophic scar (HS), keloid, atopic dermatitis (AD), oral lichen planus (OLP), chronic eczema, and rosacea.
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