Related Experiment Video
Updated: May 26, 2025
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
Published on: August 24, 2017
Based on the resting-state functional magnetic resonance imaging reveals the causal relationship between the brain
Yuchao Liu1,2, Chunli Li1, Linli Yao1
1Department of Otolaryngology, Head and Neck Surgery, Affiliated to Tongji Medical College, Wuhan Hospital of Integrated Chinese and Western Medicine, Huazhong University of Science and Technology, 215 Zhongshan Avenue, Wuhan, Hubei Province, 430022, China.
Objectives:
Tinnitus affects millions worldwide. Its neural mechanisms remain unclear. This study aimed to explore the causal relationships between brain functional networks and tinnitus risk using Mendelian randomization (MR) analyses.
Methods:
We performed MR analyses using brain activity data from resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data from genome-wide association studies (GWAS). A total of 191 brain features, including amplitude traits and functional connectivity measures, were selected based on their genetic associations.
Results:
Forward MR analyses showed that increased activity in the parietal and inferior frontal regions was associated with a 41% reduction in tinnitus risk (OR = 0.59, p = 1.8 × 10-4). In contrast, increased activity in the precuneus, angular gyrus, and frontal areas was linked to a 49% increase in tinnitus risk (OR = 1.49, p = 8.9 × 10-4). Activities in the parietal and inferior frontal regions were negatively correlated with tinnitus risk (OR = 0.72, p = 0.0037). Additionally, higher activity in the parietal, frontal, and temporal regions doubled the risk (OR = 2.02, p = 0.015). Reverse MR showed that stronger connectivity between frontal and temporal regions was inversely related to tinnitus risk (beta = - 0.056, p = 0.049).
Conclusions:
Specific brain activity and connectivity patterns are causally linked to tinnitus.
More Related Videos
12:09Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
