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Updated: May 26, 2025

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery

Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery

Published on: May 4, 2022

Risk factors for malignant solid pulmonary nodules: a meta-analysis.

Yantao Yang¹, Xuancheng Li², Yaowu Duan¹

¹Department of Thoracic and Cardiovascular Surgery, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, No. 519 Kunzhou Road, Xishan District, Kunming City, Yunnan Province, China.

|February 21, 2025

Summary

Malignant solid lung nodules (MSPN) are more likely to present with spiculate signs, vascular convergence, and lobulated features compared to benign solid pulmonary nodules (BSPN). These imaging characteristics, along with age, gender, and family history, aid in distinguishing malignant from benign nodules.

Keywords:

Meta-analysis Mmalignant Risk factors Ssolid pulmonary nodules

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Area of Science:

Pulmonology
Radiology
Oncology

Background:

Clinical and imaging features can help differentiate benign from malignant solid lung nodules.
Specific distinguishing characteristics remain a subject of debate.
Identifying reliable risk factors is crucial for informed clinical decision-making.

Purpose of the Study:

To identify risk factors for malignant solid lung nodules (MSPN).
To support clinical decision-making in the diagnosis of lung nodules.
To provide a comprehensive meta-analysis of imaging and clinical features associated with malignancy.

Main Methods:

A systematic meta-analysis was conducted.
Databases searched included PubMed, Embase, Web of Science, Cochrane Library, Scopus, Wanfang, CNKI, VIP, and CBM.
Data from 32 studies (7758 nodules) were analyzed using Stata 16.0.

Main Results:

Spiculate signs, vascular convergence, lobulated signs, air bronchogram, pleura traction, border blur, and vacuole signs were significantly associated with MSPN.
Older age, female gender, larger nodule diameter, and family history of cancer also increased malignancy risk.
Lower incidence of calcification was observed in MSPN compared to BSPN.

Conclusions:

Spiculate sign, vascular convergence, lobulated sign, diameter, border blur, vacuole sign, age, gender, family history of cancer, pleura traction, air bronchogram sign, and calcification are significant predictors of malignancy in solid pulmonary nodules (SPNs).
These findings can influence clinical management strategies.
Further large-scale studies are recommended to validate these predictive markers.