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Related Experiment Videos

Diarrhea associated with typhoid fever.

S K Roy, P Speelman, T Butler

    The Journal of Infectious Diseases
    |June 1, 1985
    PubMed
    Summary

    Typhoid fever diarrhea involves significant fluid loss and fecal leukocytes. Treatment with chloramphenicol effectively resolves these symptoms, improving patient outcomes.

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    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Microbiology

    Background:

    • Typhoid fever, caused by Salmonella Typhi and Paratyphi A, is a significant global health concern.
    • Diarrhea is a common and debilitating symptom of typhoid fever, impacting patient recovery.
    • Understanding the specific characteristics of typhoid diarrhea is crucial for effective management.

    Purpose of the Study:

    • To investigate the pathogenesis of diarrhea in patients with confirmed typhoid fever.
    • To analyze stool output and fecal composition in typhoid fever patients.
    • To evaluate the impact of chloramphenicol treatment on typhoid-associated diarrhea.

    Main Methods:

    • Selected 42 patients with positive blood cultures for Salmonella Typhi/Paratyphi A and diarrhea.
    • Measured stool output and analyzed fecal composition (red blood cells, leukocytes, protein, electrolytes, pH).
    • Monitored patient response to chloramphenicol treatment.

    Main Results:

    • Patients experienced significant liquid stool output (mean 45 ml/kg) and prolonged diarrhea (mean 5.8 days).
    • Stools contained elevated levels of leukocytes (mean 4,950/mm3) and protein (mean 9.3 g/L).
    • Chloramphenicol treatment led to daily improvements in fever and stool output.

    Conclusions:

    • Diarrhea in typhoid fever is characterized by high purging rates, liquid stools, and the presence of fecal leukocytes and protein.
    • Chloramphenicol is an effective treatment for resolving diarrhea associated with typhoid fever.
    • The findings provide insights into the pathophysiology of typhoid diarrhea.

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