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Updated: May 26, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Infectious mononucleosis is a more realistic target for preventing multiple sclerosis.
Gavin Giovannoni1, Christopher H Hawkes1, Jeannette Lechner-Scott2
1Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Preventing Epstein-Barr virus (EBV) infection, particularly infectious mononucleosis (IM), through vaccination is key to preventing multiple sclerosis (MS). An EBV vaccine could significantly reduce MS incidence by targeting a necessary precursor infection.
Area of Science:
- Virology
- Neuroimmunology
- Epidemiology
Background:
- Epstein-Barr virus (EBV) infection is epidemiologically linked as a necessary factor for developing multiple sclerosis (MS).
- Individuals who are EBV-negative appear protected from MS, suggesting a primary prevention target.
- Late symptomatic EBV infection (infectious mononucleosis) poses a greater MS risk than early asymptomatic infection.
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