Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in Retinal Microvasculature During Healthy Pregnancy Measured by AO.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation.

Translational psychiatry·2026
Same author

Targeted proteomics reveal association between maternal biomarkers and child body weight in the first year of life.

Journal of the Endocrine Society·2026
Same author

[Surrogate markers in chronic kidney disease : Estimated glomerular filtration rate and albuminuria in clinical practice and in studies].

Innere Medizin (Heidelberg, Germany)·2026
Same author

Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Targeting risk factors and strategies for prevention of peripheral neuropathy: focus on B-vitamin deficiencies and metabolic diseases.

Neurological research and practice·2026

Related Experiment Video

Updated: May 26, 2025

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

3.5K

Slope Chain Code-based scale-independent tortuosity measurement on retinal vessels.

Zian Fanti1, Ulf-Dietrich Braumann2, Franziska G Rauscher3

  • 1Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas (IIMAS), Universidad Nacional Autónoma de México (UNAM), Apdo. 20-126, Ciudad de México 1000, México.

Experimental Eye Research
|February 22, 2025
PubMed
Summary

A new scale-invariant metric, the Extended Slope Chain Code, accurately measures retinal vascular tortuosity. A novel database, SCALE-TORT, was created to validate this metric

Keywords:
Extended Slope Chain CodeFundus photographyRetinal vesselsScale invarianceScanning laser ophthalmoscopyTortuosity measurement

More Related Videos

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.4K
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

7.1K

Related Experiment Videos

Last Updated: May 26, 2025

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
12:28

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

3.5K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.4K
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

7.1K

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Retinal vascular tortuosity is a key biomarker for systemic and vascular diseases.
  • Accurate measurement of tortuosity is crucial for clinical applications.
  • Existing metrics may lack scale invariance, limiting their reliability across different imaging settings.

Purpose of the Study:

  • To introduce a novel, scale-invariant metric for measuring retinal blood vessel tortuosity.
  • To develop and present the SCALE-TORT database for evaluating scale invariance on real retinal vessel data.
  • To compare the proposed metric against existing tortuosity measurement methods.

Main Methods:

  • Developed a scale-invariant tortuosity metric based on the Extended Slope Chain Code.
  • Created the SCALE-TORT database using semi-automated methods from paired retinal images (fundus camera and scanning laser ophthalmoscope).
  • Evaluated ten tortuosity metrics, including the proposed one, through three experiments using synthetic and real retinal data.

Main Results:

  • The Extended Slope Chain Code metric demonstrated optimal scale invariance and sensitivity to tortuosity changes.
  • The SCALE-TORT database provides a valuable resource for assessing scale invariance in retinal imaging.
  • The proposed metric offers easy implementation and reliable performance compared to other methods.

Conclusions:

  • The novel Extended Slope Chain Code metric is a robust tool for assessing retinal vascular tortuosity.
  • The SCALE-TORT database facilitates the validation of scale-invariant tortuosity metrics.
  • This work advances the use of retinal vascular tortuosity as a reliable clinical biomarker.