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Neuroprotective lindenane sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm
Lie-Feng Ma1, Shan-Rong Luo1, Qian-Qing Liu1
1Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, PR China.
Abstract:
Eleven previously undescribed lindenane sesquiterpenoids, lindaggrols A-K (1-11), were isolated from the roots of Lindera aggregata (Sims) Kosterm, together with five known ones. Their structures were elucidated by HR-ESI-MS, NMR, and single-crystal X-ray diffraction analyses. Lindaggrol A (1) is an undescribed rearranged dinor-lindenane with an unprecedented 3/5/5 tricyclic scaffold. All isolated compounds were assayed for their neuroprotective effects against erastin-induced ferroptosis in HT-22 cells. Among them, 3, 12 and 14 exhibited significant neuroprotective activities with EC50 values ranging from 1.4 to 8.7 μM.
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