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Advances in understanding therapeutic mechanisms of probiotics in cancer management, with special emphasis on breast

A S Angel Nama1, G Mary Sandeepa1, Viswanath Buddolla2

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European Journal of Pharmacology
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PubMed
Summary
This summary is machine-generated.

Probiotics show promise in fighting breast cancer by boosting the immune system and enhancing therapies. Further research is needed to fully understand their role in cancer treatment and optimize their use.

Keywords:
Anticancer mechanismsBreast cancerCancer therapeuticsGut healthImmunomodulationProbiotics

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Area of Science:

  • Oncology
  • Microbiology
  • Immunology

Background:

  • Rising global cancer incidence, especially breast cancer, demands novel treatments.
  • Probiotics, known for gut health benefits, exhibit immunomodulatory and anticancer properties.
  • Their potential as adjuvant therapy in oncology is gaining attention.

Purpose of the Study:

  • To review the therapeutic mechanisms of probiotics in breast cancer.
  • To examine probiotic anticancer efficacy via metabolic, immune, and molecular pathways.
  • To discuss recent advancements and clinical applications of probiotics in cancer therapy.

Main Methods:

  • Literature review of preclinical and clinical studies on probiotics and breast cancer.
  • Analysis of probiotic mechanisms including immunomodulation and tumor microenvironment modulation.
  • Evaluation of probiotics as gene expression systems and drug delivery vectors.

Main Results:

  • Probiotics can enhance existing cancer therapies and reduce side effects.
  • They modulate the tumor microenvironment and exhibit anticancer effects.
  • Personalized probiotic interventions and novel delivery systems are emerging.

Conclusions:

  • Probiotics offer promising adjuvant strategies for breast cancer treatment.
  • Translating preclinical findings to clinical practice requires addressing challenges.
  • Further investigation into probiotics, the microbiome, and cancer treatment is warranted.