Electrophysiology in disorders of consciousness

Electroencephalography (EEG) has emerged as a powerful tool in the diagnosis, characterization, and prognostication of patients with disorders of consciousness (DoC). EEG is a well-established monitoring tool for the treatment of specific patient populations with impaired consciousness, such as those with status epilepticus and cardiac arrest. The interrogation of neuronal circuitry using evoked and event-related potentials adds prognostic information in comatose individuals. Novel paradigms integrating transcranial magnetic stimulation may provide insights into the underpinnings of arousal and awareness. Covert consciousness, or willful brain activation to motor commands in behaviorally unresponsive patients, may be diagnosed using EEG recordings and has been linked to better outcomes. These advanced EEG methods are increasingly being explored and integrated into the management of DoC patients.