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Updated: May 26, 2025
12:05
Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni
Published on: January 14, 2018
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Human schistosomiasis
Dora Buonfrate1, Teresa Cristina A Ferrari2, Ayola Akim Adegnika3
1Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.
Lancet (London, England)
|February 22, 2025
Summary
Schistosomiasis, a neglected tropical disease, is caused by Schistosoma parasites transmitted via freshwater snails. Treatment involves praziquantel, crucial for mass drug administration in endemic communities.
Area of Science:
- Tropical Medicine
- Parasitology
- Infectious Diseases
Background:
- Schistosomiasis is a neglected tropical disease caused by Schistosoma blood flukes.
- It is prevalent in tropical and subtropical regions, transmitted through freshwater snails.
- Infections can lead to acute (Katayama fever) and chronic conditions affecting various organs.
Purpose of the Study:
- To provide a comprehensive overview of schistosomiasis, including its epidemiology, clinical manifestations, diagnosis, and treatment.
- To highlight the public health significance of this neglected tropical disease.
- To emphasize current control strategies and the role of praziquantel.
Main Methods:
- Review of existing literature on Schistosoma infections.
- Analysis of clinical presentations and pathological outcomes.
- Summary of diagnostic approaches and therapeutic interventions.
Main Results:
- Schistosomiasis manifests as intestinal or urogenital disease with severe complications like hepatic fibrosis, portal hypertension, renal failure, and bladder cancer.
- Diagnosis relies on egg detection, often with limited sensitivity.
- Praziquantel is the primary treatment and key component of mass drug administration programs.
Conclusions:
- Schistosomiasis poses a significant global health burden, necessitating integrated control strategies.
- Effective management relies on early diagnosis and widespread access to praziquantel.
- Continued research and public health efforts are vital to combat this neglected tropical disease.
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