Related Experiment Video
Updated: May 26, 2025

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
Published on: January 12, 2024
Diabetes and risk of premature atherosclerotic cardiovascular disease
Jamal S Rana1, Fatima Farrukh2, Howard H Moffet3
1Division of Cardiology, Kaiser Permanente Oakland Medical Center, USA; Division of Research, Kaiser Permanente Northern California, USA.
Background And Aim:
Risk of premature atherosclerotic cardiovascular disease (ASCVD) attributable to diabetes is poorly understood. We evaluated the impact of diabetes on future risk of ASCVD in young men and women.
Methods And Results:
Observational cohort study of young adults (ages 30-55 years) without established ASCVD (as of January 1, 2006) who were members of Kaiser Permanente Northern California, an integrated healthcare delivery system. Adjusted demographics (age, race) and traditional risk factors (hypertension, LDL-cholesterol, HDL- C, total cholesterol, smoking). Models were specified to estimate risk ratios (RRs) for incident ASCVD events by diabetes status: no diabetes (reference) versus diabetes with no treatment, with oral hypoglycemic (OH) only and with OH plus insulin. Incident ASCVD events were defined as a composite of nonfatal myocardial infarction, ischemic stroke, or coronary heart disease death through December 31, 2020. In fully adjusted models, individuals with diabetes using insulin exhibited a 5-fold higher risk among women (RR: 5.44; 95 % CI: 4.90-6.05) and a 3-fold higher risk among men (RR: 3.13; 95 % CI: 2.84-3.45) for incident ASCVD events compared to those without diabetes.
Conclusions:
A proactive stance towards ASCVD risk management in young individuals with diabetes, healthcare professionals can help improve the morbidity and mortality associated with this complex interplay of metabolic and cardiovascular disease.
More Related Videos
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Related Concept Videos
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Type 2 and Gestational
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Psychoneuroimmunology: Diabetes and Cancer
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...