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Global prevalence of hydrocele in infants and children: a systematic review and meta-analysis
Nader Salari1, Mahan Beiromvand2, Reza Abdollahi3
1Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Insights
Pediatric hydrocele, a common congenital condition in infants, affects 1 in 1000 live births. Early screening and health policies are crucial to address undiagnosed cases in children and prevent long-term consequences.
Area of Science:
- Pediatric Urology
- Public Health
- Epidemiology
Background:
- Pediatric hydrocele is a common congenital condition in newborns.
- Untreated cases can lead to permanent adverse effects in adulthood.
- Understanding global prevalence is vital for health policy development.
Purpose of the Study:
- To investigate the global prevalence of pediatric hydrocele in infants and children.
- To provide essential data for health policymakers regarding this condition.
Main Methods:
- Systematic literature search across multiple databases (PubMed, Scopus, Web of Science, Embase, ScienceDirect, Google Scholar).
- Keywords: "Prevalence", "Outbreak hydrocele", "Infant", "Child".
- Meta-analysis using a random-effects model with heterogeneity assessed by the I² index.
Main Results:
- Global prevalence in infants (1-2 weeks) is 0.001% (1 per 1000 live births) based on 5 studies (70,961 infants).
- Global prevalence in children (7-12 years) is 0.0034% (3.4 per 1000 children) based on 3 studies (278,597 children).
Conclusions:
- A significant global prevalence of pediatric hydrocele exists, particularly in infants.
- Undiagnosed or recurrent cases in children necessitate improved medical screening.
- Implementation of health policies is recommended to mitigate prevalence and adverse outcomes.
Background:
Pediatric hydrocele is a congenital pathology commonly diagnosed in newborns. Also, untreated pediatric hydrocele can induce adverse permanent consequences in adulthood. This study aimed to investigate the global prevalence of pediatric hydrocele in infants and children, as a necessary factor for health policymakers.
Methods:
Databases of PubMed, Scopus, Web of Science, Embase, ScienceDirect, and Google Scholar search engine were systematically searched for studies reporting the prevalence of pediatric hydrocele in infants and children. The main keywords of "Prevalence", "Outbreak hydrocele", "Infant", and "Child" were used in this regard. Screenings were applied to achieve eligible papers and a quality control process was conducted to select middle to high-quality papers. Finally, the random effect model was used to perform meta-analysis, and heterogeneity was checked by the I2 index. Data analysis was applied with CMA (v.2) software.
Results:
Following the assessment of 5 eligible studies with a sample size of 70,961 infants (1-2 weeks), the global prevalence of hydrocele in infants was found 0.001% (95%CI:0.00007-0.018, 1 per 1000 live births). In the review of 3 studies with a sample size of 278,597 children (7-12 years), the global prevalence of hydrocele in children was reported 0.0034% (95%CI:0.00004-0.21), 3.4 per 1000 children).
Conclusion:
According to the analyzed studies, a relatively high prevalence of hydrocele in infants was reported, globally. Besides, there were undiagnosed or recurrent pediatric hydrocele cases in children which need more precise medical screening. Thus, it is necessary to implement health policies to reduce the prevalence of pediatric hydrocele and associated adverse consequences.
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