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Correlation between intradialytic blood pressure variability and cognitive impairment in patients on maintenance

Jingfang Wan1,2, Jun Liu1,2, Jing Pan3

  • 1Department of Nephrology, Daping hospital, Army Medical Center of PLA, No. 10, Changjiang Road, Daping, Yuzhong District, Chongqing, 400042, China.

BMC Nephrology
|February 22, 2025
PubMed

Insights

High blood pressure variability during dialysis is linked to cognitive decline in hemodialysis patients. Average real variability (ARV) of systolic blood pressure (SBP) may indicate mild cognitive impairment (MCI) in this population.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiology

Background:

  • The link between intradialytic blood pressure variability (BPV) and mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients remains unclear.
  • Understanding this relationship is crucial for managing cognitive health in MHD patients.

Purpose of the Study:

  • To investigate the correlation between intradialytic blood pressure variability (BPV) and cognitive impairment (CI) in maintenance hemodialysis (MHD) patients.
  • To identify specific BPV indices associated with MCI in this cohort.

Main Methods:

  • Collected intradialytic systolic blood pressure (SBP) data within 3 months prior to cognitive assessment.
  • Calculated four BPV indices: standard deviation (SD), coefficient of variation (CV), average real variability (ARV), and RANGE.
  • Assessed overall cognitive function using the Montreal Cognitive Assessment (MoCA) scale.

Main Results:

  • Enrolled 170 MHD patients with 6662 dialysis records and 26,580 SBP measurements.
  • MCI prevalence was high at 78.24%.
  • Intradialytic SBP ARV was significantly higher in patients with MCI compared to the non-MCI group (8.91 vs. 7.60, P=0.042). No significant differences were found in mean SBP or other BPV indices.

Conclusions:

  • Elevated intradialytic SBP ARV is closely associated with MCI in MHD patients.
  • High SBP ARV may serve as a potential indicator for MCI in maintenance hemodialysis patients.
Abstract

Keywords:
Blood pressure variabilityCognitive impairmentHemodialysis

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