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Updated: Jun 22, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Copper-based metal-organic frameworks for antitumor application.

Yangwei Qian¹, Chenxi Wang¹, Ruru Xu¹

¹School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, People's Republic of China.

Journal of Nanobiotechnology

|February 22, 2025

Summary

Copper-based metal-organic frameworks (Cu-MOFs) show promise for cancer treatment due to their catalytic and photothermal properties. This review explores their applications in drug delivery, therapy, and imaging for enhanced antitumor effects.

Keywords:

Antitumor application Antitumor therapy Cu-MOFs Drug carrier Theranostic Tumor imaging

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Synthesis and Characterization of Functionalized Metal-organic Frameworks

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Multifunctional materials and combined therapeutic strategies are crucial for effective cancer treatment.
Copper-based metal-organic frameworks (Cu-MOFs) exhibit significant potential in antitumor applications due to their catalytic, biocompatible, and photothermal conversion properties, alongside metabolic regulation capabilities.

Purpose of the Study:

To provide a comprehensive overview of copper-based metal-organic frameworks (Cu-MOFs) for antitumor applications.
To summarize representative ligands, synthetic methods, antitumor mechanisms, and recent applications of Cu-MOFs in cancer therapy.

Main Methods:

Literature review focusing on Cu-MOFs in antitumor applications.
Summarization of recent advancements in Cu-MOF-based drug carriers, antitumor therapy, tumor imaging, and theranostics.

Main Results:

Cu-MOFs are versatile platforms for drug delivery, photothermal therapy, and tumor imaging.
Recent studies highlight the efficacy of Cu-MOFs in various antitumor strategies, including theranostics.
Examples of specific Cu-MOF applications in cancer treatment are presented.

Conclusions:

Cu-MOFs offer a promising avenue for developing advanced antitumor strategies.
Challenges and future perspectives for the clinical application of Cu-MOFs in oncology are discussed.