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Copper-catalyzed sulfonylation of alkenes with CH3SSO3Na
Xiaoli Chen1,2, Ge Wu3,4
1Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Abstract:
A successful methodology for the copper-catalyzed dehydrogenated methylsulfonylation of alkenes utilizing CH3SSO3Na in conjunction with hypervalent iodine reagents was successfully established. This method offers a practical avenue to obtain allyl methyl sulfones and alkenyl methyl sulfones by forming C-S bonds. Using the C-H bond oxidation sulfonylation strategy with alkenes and Bunte salts, we successfully synthesized a total of twenty two compounds, including four examples of deuterium-substituted molecules, and demonstrated one example of a scale-up reaction.
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