Pediatric Ewing's Sarcoma and Permanent Chemotherapy-Induced Alopecia: A Case-Control Study

Permanent chemotherapy-induced alopecia (PCIA), defined as the persistence of hair loss for > 6 months following chemotherapy cessation, is a rare pediatric diagnosis. A retrospective chart review was conducted to characterize cases of PCIA not previously reported in pediatric Ewing's sarcoma (ES) patients after completion of therapeutic chemotherapy, comparing demographic factors, cumulative chemotherapy dosing, family history of hair loss, and treatment methodologies with a control group. Of 12 patients with an history of pediatric ES, three were diagnosed with PCIA. Our findings suggest that PCIA can occur after treatment for ES in the pediatric population and that treatments, including topical and oral minoxidil, can be beneficial but may not result in complete hair regrowth.