The dubious case of Urbanorum: a call to strengthen global pathogen verification mechanisms

The detection and validation of novel pathogens have become increasingly important, as seen with the emergence of COVID-19 and mpox. Current detection and response capacities, especially in resource-poor regions, are insufficient, highlighting the key role of clinical laboratories. Despite the strides made by national and supranational agencies in targeting viruses and bacteria, parasites have been largely overlooked. The case of Urbanorum, a purportedly novel intestinal parasite reported from South America, illustrates the challenges in validating new pathogens. Compelling microscopic images have fostered belief in the existence and aetiological role of Urbanorum, posing grave challenges for health-care workers with poor parasitological knowledge, who might accept such results at face value and administer unnecessary treatments to affected individuals. Although the number of publications is scarce, these sources present a seemingly credible narrative that spreads through local social media. However, doubts about the existence of Urbanorum persist due to the absence of genetic and molecular analyses and inconsistencies in epidemiological data. This situation exemplifies the need for robust global pathogen verification mechanisms and authoritative guidance from organisations such as the US Centers for Disease Control and Prevention (CDC) and WHO to prevent misinformation and aid clinical judgement. A Latin American regional CDC could be instrumental in verifying claims of novel pathogens and providing credible guidance at both local and global levels. This Personal View emphasises the urgent need for enhanced global coordination, improved diagnostic methodologies, and reliable information dissemination to effectively manage threats regarding emerging pathogens.