Related Experiment Video
Updated: May 26, 2025
11:40
High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
Published on: April 28, 2022
2.6K
Causal relationship between gut microbiota and ageing: A multi-omics Mendelian randomization study.
Guolin Zhang1, Yuqing Lu2, Zhen Wang3
1Department of Cardiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Archives of Gerontology and Geriatrics
|February 23, 2025
Summary
This study reveals causal links between gut microbiota and aging, highlighting Akkermansia muciniphila
Area of Science:
- Microbiology
- Genetics
- Gerontology
Background:
- Observational studies suggest a gut microbiota-aging link.
- Causal relationships remain unclear.
Purpose of the Study:
- To investigate the causal relationship between gut microbiota and aging using bidirectional two-sample Mendelian randomization (TSMR).
Main Methods:
- Utilized genome-wide association studies (GWAS) summary statistics for gut microbiota and aging phenotypes.
- Performed TSMR and reverse Mendelian randomization (MR) analyses.
- Investigated Akkermansia muciniphila's role in aging using molecular and C. elegans models.
Main Results:
- Identified 44 causal relationships between gut microbiota and aging.
- Akkermansia muciniphila showed causal links to mvAge, lean mass, and grip strength.
- Akkermansia muciniphila extended lifespan and improved mobility in C. elegans.
Conclusions:
- TSMR analysis identified significant causal links between gut microbiota and aging, especially Akkermansia muciniphila.
- Experimental data support Akkermansia muciniphila's anti-aging effects.
- This research provides a basis for future studies on gut microbiota and aging.
