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Design and implementation of a risk-adapted, longitudinal, theory-driven medication adherence intervention: A
Benyam Muluneh1, Maurlia Upchurch2, Bethel Belayneh3
1Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA.
Research in Social & Administrative Pharmacy : RSAP
|February 23, 2025
Summary
This study develops a medication adherence intervention for oral anticancer agents (OAAs) to improve patient outcomes. The risk-adapted, longitudinal approach aims for scalable and sustainable support in routine cancer care.
Area of Science:
- Oncology
- Implementation Science
- Behavioral Science
Background:
- Oral anticancer agents (OAAs) have transformed cancer care, but suboptimal patient adherence is a significant challenge in real-world settings.
- Developing effective strategies to improve adherence to OAAs is crucial for maximizing treatment efficacy and patient outcomes.
Purpose of the Study:
- To design, implement, and evaluate a multi-phasic, hybrid effectiveness-implementation trial for a risk-adapted, longitudinal medication adherence intervention.
- To address cognitive, behavioral, and environmental barriers impacting patient adherence to OAAs.
Main Methods:
- The study employs social cognitive theory, intervention mapping, and implementation science principles.
- Phase 1 involves identifying barriers and refining strategies through expert input and interviews.
- Phase 2 focuses on patient-centered feedback to tailor the intervention, followed by a pilot in Phase 3 to assess effectiveness and feasibility.
Main Results:
- This section is not applicable as the abstract describes a study protocol and not results.
- The protocol outlines a phased approach to intervention development and evaluation.
Conclusions:
- The trial aims to establish a scalable and sustainable model for medication adherence support in cancer care.
- Successful implementation has broad implications for enhancing patient outcomes and integrating adherence monitoring into routine clinical practice.
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