Radioactive Diselenide Bonded Covalent Organic Framework
Liang Zhang1,2, Shuo Wang1, Qi-Chao Yang1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, China.
Advanced Materials (Deerfield Beach, Fla.)
|February 24, 2025
Summary
Researchers developed a novel radioactive covalent organic framework (COF) using diselenide bonds. This material releases drugs upon irradiation, enhancing radiotherapy by promoting PANoptosis and improving the tumor microenvironment.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Covalent organic frameworks (COFs) show promise for biomedical applications.
- The stability and drug-release capabilities of COFs are crucial for therapeutic efficacy.
- Designing responsive biomaterials requires innovative chemical strategies.
Purpose of the Study:
- To synthesize a novel radioactive COF with labile diselenide bonds for controlled drug release.
- To investigate the therapeutic potential of this COF in cancer treatment.
- To explore the application of clip-off chemistry in developing advanced biomaterials.
Main Methods:
- Synthesis of a diselenide-bonded COF (PorSe-CuPt) incorporating Cu and Pt ion porphyrin units.
- Incorporation of the drug molecule CBL0137 into the COF pores.
- Irradiation-induced cleavage of diselenide bonds for drug release.
- Evaluation of X-ray absorption, oxygen enrichment, and PANoptosis induction.
Main Results:
- The synthesized PorSe-CuPt COF effectively released the carried drug molecule upon irradiation.
- Pt²⁺ promoted X-ray absorption, while Cu²⁺ enriched oxygen, enhancing therapeutic effects.
- Robust PANoptosis was achieved, alongside an improved immunosuppressive tumor microenvironment.
- The study demonstrated enhanced radiotherapy effectiveness.
Conclusions:
- The integration of labile diselenide bonds into COFs enables clip-off chemistry for controlled drug delivery.
- This approach leads to highly responsive and compatible biomaterials for biomedical applications.
- The developed radioactive COF shows significant potential for improving cancer radiotherapy outcomes.
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