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Updated: May 26, 2025

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Nanocapsules with dual-targeting of cell and mitochondria functions for enhanced hypoxia-activated drug therapy
1School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China. yingshug@126.com.
Abstract:
The cell and mitochondria dual-targeting nanocapsules reported here could exacerbate tumor hypoxia to activate a hypoxia-activated drug, tirapazamine, producing benzotriazinyl radicals and ˙OH, which are capable of killing tumor cells via DNA damage. In addition, mitochondrial dysfunction can result from the accumulation of ˙OH. This chain reaction triggers a surge in ROS that can effectively increase the therapeutic efficiency of the nanocapsules.
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