Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Novel 3D Bioprinting Strategy for Bioengineering of Urethra with Clinical Relevance.

Tissue engineering. Part A·2026

Same author

Assessing health-regulating ecosystem services in rural landscapes: An integrated approach using physiological and visual semantic data.

Journal of environmental management·2026

Same author

HRRT: hierarchical reinforcement learning for renal replacement therapy decision support.

NPJ digital medicine·2026

Same author

Maternal methionine supplementation regulates skeletal muscle development through N<sup>6</sup>-methyladenosine mRNA methylation in broiler offspring.

Animal nutrition (Zhongguo xu mu shou yi xue hui)·2026

Same author

Spatial imaging of water oxidation on single-particle catalysts.

Nature nanotechnology·2026

Same author

A membrane-fused theranostic nanoplatform for real-time ROS imaging and mitochondrial resuscitation-driven barrier repair in acute kidney injury.

Materials today. Bio·2026

Search research articles

Related Experiment Video

Updated: May 26, 2025

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

Evaluating artifact-free four-dimensional computer tomography with 16 cm detector array.

Inhwan Yeo¹, Wei Nie¹, Jiajin Fan¹

¹Department of Advanced Radiation and Proton Therapy, INOVA Schar Cancer Institute, Fairfax, Virginia, USA.

Journal of Applied Clinical Medical Physics

|February 24, 2025

Summary

This summary is machine-generated.

The 16 cm-array axial four-dimensional computed tomography (4DCT) system demonstrated superior accuracy in imaging lung tumors during irregular breathing compared to the 4 cm-array system. This 4DCT imaging is crucial for precise radiation therapy planning.

Keywords:

16 cm long detector 4DCT artifacts respiration irregularity

More Related Videos

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Published on: July 15, 2021

Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging

Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging

Published on: July 12, 2022

Related Experiment Videos

Last Updated: May 26, 2025

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration

Published on: November 23, 2019

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Published on: July 15, 2021

Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging

Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging

Published on: July 12, 2022

Area of Science:

Medical Imaging
Radiation Oncology
Computed Tomography

Background:

Accurate imaging of lung tumors during radiation therapy is critical.
Respiration-induced motion can significantly impact image quality and treatment accuracy.
Four-dimensional computed tomography (4DCT) is used to account for respiratory motion.

Purpose of the Study:

To compare the performance of a 16 cm-array axial 4DCT system against a 4 cm-array system.
To evaluate their effectiveness in the presence of irregular respiration patterns.
To assess image accuracy for lung tumor targeting in dynamic phantom studies.

Main Methods:

A phantom lung cylinder with a spherical target was subjected to 10 motion traces simulating CyberKnife treatment scenarios.
Images were acquired using a 16 cm-array and a 4 cm-array 4DCT system under simulated irregular breathing.
Target dimensions, overlap ratios, and Hounsfield units were compared against a step-wise helical scan ground truth.

Main Results:

The 16 cm-array 4DCT showed better agreement with the ground truth in target length and overlap ratios compared to the 4 cm-array.
The 4 cm-array 4DCT exhibited significant disagreement, particularly in maximum intensity projection (MipCT) and phase (MP) CT reconstructions.
While the 16 cm-array 4DCT improved accuracy, limitations in motion averaging and phase sorting affected perfect reconstruction.

Conclusions:

The 16 cm-array axial 4DCT system is recommended to mitigate the effects of respiratory irregularities in lung tumor imaging.
Utilizing the 16 cm-array 4DCT can enhance the precision of radiation therapy planning for lung cancer patients.