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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Related Experiment Video

Updated: May 26, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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Pigmentary demarcation lines: Three cases encapsulating a benign condition.

Natalia Chalupczak1, Alexander Woods2, Allison Kirchner2

  • 1Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

Journal of Family Medicine and Primary Care
|February 24, 2025
PubMed
Summary

Pigmentary demarcation lines (PDL) are distinct skin markings showing abrupt changes in pigmentation. This review highlights their occurrence and benign nature across diverse populations to increase medical awareness.

Area of Science:

  • Dermatology
  • Human Pigmentation Biology

Background:

  • Pigmentary demarcation lines (PDL) present as abrupt transitions between hyperpigmented and normal skin.
Keywords:
Cutaneous neurogenic inflammationVoigt-Futcher linesdermatologyhyperpigmentationpigmentary demarcation lines

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  • These lines are commonly observed in individuals of African, Hispanic, and Japanese descent, but can occur in Caucasians.
  • PDL distribution is theorized to align with "Voigt's lines," associated with peripheral nerve pathways.