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Updated: Dec 26, 2025

Author Spotlight: Separation of Coral Host Tissues and Algal Symbionts and Analyzing Their Metabolites
Published on: October 13, 2023
Structurally Diverse New Metabolites from Three Hadal Trench-Derived Microorganisms
Qingyun Peng1, Wenjia Huang1, Xiao Zhang2
1Research Center for Deepsea Bioresources, Sanya, Hainan 572025, China.
Abstract:
Two new tetraene lactone derivatives (1 and 2), two new α-pyrone derivatives (3 and 4), three compounds reported as natural products for the first time [an α-pyrone derivative (5), an indole-diketopiperazine alkaloid (6), and a β-amino acid derivative (8)], and 11 known compounds (7, 9-18), were obtained from microorganisms isolated from hadal trench sediments in the Pacific Ocean. Their structures were determined using NMR, HRESIMS, optical rotatory dispersion (ORD) spectra, NMR calculations followed by DP4+ analysis, electronic circular dichroism (ECD) calculations, X-ray crystallography analysis, and advanced Marfey's and modified Mosher eater methods. Microbial broth dilution assay suggested that compounds 6-11 and 15 had weak antibacterial effects.
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