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Targeted Cancer Therapies

Targeted Cancer Therapies

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Related Experiment Video

Updated: May 26, 2025

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

Layer-by-Layer Multitargeting Strategy for Enhanced Photothermal Therapy.

Shilei Ren^1,2, Qian Wang³, Chongqing Zhang⁴

¹Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China.

|February 24, 2025

Summary

This summary is machine-generated.

Researchers developed a novel self-photothermal nanoplatform using polyphenol-metal self-assembly. This "layer-by-layer targeting" strategy enhances tumor targeting for more effective photothermal therapy with fewer side effects.

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Published on: September 17, 2013

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One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

Published on: September 17, 2013

Area of Science:

Biomedical Engineering
Nanotechnology
Materials Science

Background:

Photothermal therapy (PTT) offers precise tumor treatment with minimal toxicity.
Active targeting of nanoprobes improves PTT efficacy and reduces side effects.
Traditional targeting methods involve complex steps and potential off-target risks.

Purpose of the Study:

To develop a novel self-photothermal nanoplatform for enhanced PTT.
To integrate multi-targeting molecules via a simplified self-assembly process.
To improve tumor-targeting efficiency and PTT effectiveness.

Main Methods:

Utilized polyphenol-metal self-assembly to create the Ga/Fe/HA/FA nanoplatform.
Synchronously integrated gallic acid, folic acid (FA), and hyaluronic acid (HA) via layer-by-layer assembly.
Investigated the self-assembly process for multi-targeting capabilities.

Main Results:

Successfully prepared a self-photothermal nanoplatform (Ga/Fe/HA/FA) through polyphenol-metal self-assembly.
Achieved a "layer-by-layer targeting" effect by integrating FA and HA.
Demonstrated improved tumor-targeting efficiency and reduced off-target risks compared to traditional methods.

Conclusions:

The self-assembly multi-targeting strategy simplifies experimental procedures.
This approach effectively mitigates off-target risks during circulation.
The developed nanoplatform significantly augments the effectiveness of photothermal therapy.