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Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis

Kazutoshi Hirose1, Hiroyuki Kiriyama1, Shun Minatsuki1

  • 1Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan.

International Journal of Cardiology. Heart & Vasculature
|February 24, 2025
PubMed

Insights

Systemic sclerosis (SSc) patients with coronary artery disease (CAD) experience worse long-term cardiovascular outcomes after percutaneous coronary intervention (PCI). This study highlights increased CAD complexity and adverse events in SSc patients post-PCI.

Area of Science:

  • Cardiology
  • Rheumatology
  • Vascular Medicine

Background:

  • Systemic sclerosis (SSc) is linked to increased coronary artery disease (CAD) risk and poorer outcomes.
  • Morphological characteristics and long-term cardiovascular outcomes in SSc patients with CAD are not well understood.

Purpose of the Study:

  • To investigate the characteristics and long-term cardiovascular outcomes of patients with concurrent SSc and CAD.
  • To compare CAD complexity and clinical outcomes between SSc and non-SSc patients undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • Retrospective analysis of 3,300 CAD patients undergoing PCI.
  • Propensity score-matching (1:3) comparing SSc (n=17) and non-SSc (n=51) groups.
  • Analysis included laboratory, echocardiographic, angiographic data, and clinical outcomes (cardiac death, myocardial infarction, stroke, heart failure hospitalization).

Main Results:

  • No significant differences in laboratory or echocardiographic parameters between groups.
  • CAD in the SSc group showed trends towards greater complexity, including left main trunk lesions and higher SYNTAX scores.
  • SSc patients experienced significantly more primary (cardiac death, MI, stroke) and secondary (primary outcomes + HF hospitalization) adverse events during follow-up.

Conclusions:

  • Patients with CAD and SSc have poorer long-term cardiovascular outcomes following PCI compared to those without SSc.
  • SSc is associated with more complex coronary artery disease and increased adverse cardiovascular events post-PCI.
Abstract

Keywords:
Cardiovascular outcomeCoronary artery diseasePercutaneous coronary interventionSystemic sclerosis

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