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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Updated: May 26, 2025

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Orally Administrated Inulin-Modified Nanozymes for CT-Guided IBD Theranostics.

Xinwen Li1, Lin Cao1, Jianmin Li2

  • 1Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, People's Republic of China.

International Journal of Nanomedicine
|February 24, 2025
PubMed
Summary

Inulin-coated cerium oxide nanoparticles offer a dual approach for treating inflammatory bowel disease (IBD) and monitoring inflammation using CT imaging. This innovative treatment reduces oxidative stress and inflammation in the colon, improving IBD management.

Keywords:
CT imagingantioxidationceriainflammatory bowel diseasenanozyme

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Inflammatory bowel disease (IBD) is a chronic condition with limited treatment options.
  • Excessive reactive oxygen species (ROS) contribute to IBD onset and progression.
  • Current non-invasive imaging techniques for IBD diagnosis and monitoring are suboptimal.

Purpose of the Study:

  • To develop inulin (IN)-coated cerium oxide nanoparticles (CeO2@IN NPs) for combined therapeutic and computed tomography (CT) imaging applications in IBD.
  • To evaluate the physicochemical properties, ROS scavenging ability, and CT imaging capabilities of CeO2@IN NPs in vitro.
  • To validate the therapeutic and inflammation imaging efficacy of CeO2@IN NPs in a dextran sulfate sodium (DSS)-induced colitis model.

Main Methods:

  • Synthesis and characterization of inulin-coated cerium oxide nanoparticles (CeO2@IN NPs).
  • In vitro assessment of ROS scavenging activity and biocompatibility.
  • In vivo evaluation in a DSS-induced colitis mouse model for therapeutic effects and CT imaging performance.
  • Assessment of nanoparticle traversal through the gastrointestinal tract and accumulation in the colon.

Main Results:

  • CeO2@IN NPs effectively scavenge ROS, exhibiting catalase (CAT) and superoxide dismutase (SOD) mimetic activities, protecting cells from oxidative stress.
  • Orally administered CeO2@IN NPs reached the colon, reduced intestinal inflammation, and preserved intestinal epithelial integrity in colitis model mice.
  • CeO2@IN NPs demonstrated superior CT imaging contrast in the gastrointestinal tract compared to conventional agents, particularly for inflamed colonic regions.
  • Excellent in vitro and in vivo biocompatibility of CeO2@IN NPs was confirmed.

Conclusions:

  • CeO2@IN NPs represent a novel integrated diagnostic and therapeutic tool for IBD.
  • The developed nanoparticles show significant potential for clinical application in the management and monitoring of IBD.
  • This approach offers a promising strategy for addressing the unmet clinical needs in IBD treatment and imaging.