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Advances in preclinical and clinical studies of oncolytic virus combination therapy

Wenlong Du1, Jintong Na1, Liping Zhong1,2

  • 1State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, China.

Frontiers in Oncology
|February 24, 2025
PubMed

Insights

Oncolytic viruses kill tumor cells. Combining them with other therapies like radiation, chemotherapy, and cell therapies shows promise for improved cancer treatment and clinical translation.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy

Background:

  • Oncolytic viruses selectively target and destroy cancer cells, sparing healthy ones.
  • Oncolytic viruses face challenges as monotherapies, necessitating combination strategies.
  • Combining oncolytic viruses with other treatments is a key research area.

Purpose of the Study:

  • To review oncolytic virus tumor-killing mechanisms.
  • To explore combinations of oncolytic viruses with radiotherapy, chemotherapy, immune checkpoint inhibitors, CAR-T, and CAR-NK therapies.
  • To provide insights for clinical translation of oncolytic virus combination therapies.

Main Methods:

  • Literature review of oncolytic virus mechanisms.
  • Synthesis of research on combining oncolytic viruses with various therapeutic modalities.
  • Overview of current clinical trials involving oncolytic virus combinations.

Main Results:

  • Oncolytic viruses exhibit diverse tumor-killing mechanisms.
  • Combination therapies enhance the efficacy of oncolytic viruses.
  • Clinical trials demonstrate the potential of these combined approaches.

Conclusions:

  • Oncolytic virus combination therapies offer significant potential for cancer treatment.
  • Further research and clinical trials are crucial for optimizing these treatments.
  • This review provides a foundation for advancing oncolytic virus combination therapy translation.
Keywords:
clinical trialscombined treatmentimmunityoncolytic virustumor therapy

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