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Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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Related Experiment Video

Updated: Jun 22, 2026

Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact
11:29

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[Protective Effect of Ginsenoside Rg3 on Lipopolysaccharide-Induced Neuronal-Galial Interaction Injury Model].

Xingyu Cai1, Daofeng Yang1, Xuerui Zhuo1

  • 1（ 233030） College of Clinical Medicine, Bengbu Medical University, Bengbu 233030, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|February 24, 2025
PubMed
Summary

Ginsenoside Rg3 protects neurons from lipopolysaccharide-induced injury by reducing inflammation and apoptosis. This study shows Rg3 can alleviate glial-neuronal interaction damage, offering potential therapeutic benefits.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cell Biology
Keywords:
ApoptosisGinsenoside Rg3Glial-neuronal interaction injury modelLipopolysaccharide

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