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Updated: May 26, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Simulations Reveal Unique Roles for the FXR Hinge in the FXR-RXR Nuclear Receptor Heterodimer.

Tracy Yu1, Arumay Biswas2, Namita Dube1

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

ACS Bio & Med Chem Au
|February 24, 2025
PubMed
Summary

Nuclear receptors, like FXR and RXR, form complex structures on DNA. Molecular dynamics simulations reveal diverse arrangements and highlight the hinge region's crucial role in their function.

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