Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase II Conjugation Reactions: Overview01:14

Phase II Conjugation Reactions: Overview

143
Conjugation, a key component of phase II biotransformation reactions, is a vital process in drug detoxification. It involves transferring endogenous substances like glucuronic acid, sulfate, and glycine to drugs or their metabolites formed in phase I reactions. These conjugation reactions, often catalyzed by specific enzymes, transform potentially harmful metabolites into inactive, water-soluble forms easily excreted in urine or bile. By enhancing polarity and eliminating pharmacological...
143
Conjugated Proteins02:50

Conjugated Proteins

18.2K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to "DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement".

JACS Au·2026
Same author

Magnetic activation of spherical nucleic acids enables the remote control of synthetic cells.

Nature chemistry·2025
Same author

DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement.

JACS Au·2025
Same author

Strategies and applications of synthetic cell communication.

Nature chemical biology·2025
Same author

Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides.

Journal of the American Chemical Society·2025
Same author

Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.

Chemical science·2025

Related Experiment Video

Updated: May 26, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

7.6K

Nucleic Acid Conjugates: Unlocking Therapeutic Potential.

Disha Kashyap1, Michael J Booth1,2

  • 1Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

ACS Bio & Med Chem Au
|February 24, 2025
PubMed
Summary

Nucleic acid therapeutics show promise but face delivery and targeting challenges. Covalent biochemical conjugates offer a next-generation approach to enhance drug-like properties and therapeutic potential.

More Related Videos

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

6.8K
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

9.4K

Related Experiment Videos

Last Updated: May 26, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

7.6K
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

6.8K
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

9.4K

Area of Science:

  • Biochemistry
  • Medicinal Chemistry
  • Therapeutics

Background:

  • Nucleic acids are potent therapeutic agents targeting disease-related proteins and RNA via base pairing.
  • Current challenges include limited biodistribution, inadequate delivery, and suboptimal target engagement for nucleic acid drugs.
  • Chemical backbone modifications enhance drug-like properties, but next-generation strategies are needed.

Purpose of the Study:

  • To review next-generation chemical modifications for nucleic acid therapeutics.
  • To explore the potential of covalent biochemical conjugates in improving nucleic acid drug delivery, functionality, and targeting.
  • To highlight how heterobifunctional research can expand nucleic acid therapeutic capabilities.

Main Methods:

  • Review of current literature on nucleic acid therapeutics and chemical modifications.
  • Focus on covalent biochemical conjugates as a novel approach.
  • Exploration of heterobifunctional research (e.g., PROTACs, RIBOTACs) for enhancing nucleic acid functionality.

Main Results:

  • Covalent biochemical conjugates represent a promising strategy for next-generation nucleic acid therapeutics.
  • These conjugates can significantly improve delivery, functionality, and targeting of nucleic acid drugs.
  • Leveraging heterobifunctional research can unlock enhanced target engagement for nucleic acids.

Conclusions:

  • Covalent biochemical conjugates offer a powerful approach to overcome current limitations in nucleic acid therapeutics.
  • Next-generation chemical modifications are crucial for realizing the full therapeutic potential of nucleic acids.
  • This strategy promises to make nucleic acids more effective and versatile therapeutic agents.