Research progress of corneal characteristics and changes in primary angle‑closure glaucoma (Review)

The cornea plays a crucial role in the refractive system of the eyeball, and its changes can significantly impact the visual quality of patients with glaucoma. In patients with primary angle-closure glaucoma, several corneal alterations occur, including changes in corneal thickness and curvature, modification in corneal epithelial cells and nerves, activation of inflammatory cells, and variations in the number and morphology of stromal and endothelial cells. These morphological and structural changes in the cornea are mainly influenced by acute or chronic elevation of intraocular pressure and treatment. In the present review the corneal morphological changes and regularities associated with primary angle-closure glaucoma are examined.