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Updated: May 26, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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Association between the expression of specific microRNAs and prostate cancer progression- a systematic review and

Jihad Awadallah Alrehaili1

  • 1Department of Pathology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Frontiers in Oncology
|February 24, 2025
PubMed
Abstract

Insights

MicroRNAs (miRNAs) significantly inhibit prostate cancer (PrCa) proliferation and show promise as biomarkers for predicting metastasis. Further research is needed to fully understand their role in PrCa progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarkers

Background:

  • Prostate cancer (PrCa) remains a significant health concern.
  • MicroRNAs (miRNAs) are increasingly recognized for their roles in cancer development.
  • Understanding miRNA involvement in PrCa is crucial for advancing treatment and diagnosis.

Purpose of the Study:

  • To systematically review and synthesize evidence on the significance of specific miRNAs in prostate cancer progression.
  • To evaluate the impact of miRNAs on PrCa proliferation and metastasis.
  • To assess the potential of miRNAs as diagnostic or prognostic biomarkers for PrCa.

Main Methods:

  • Systematic review and meta-analysis conducted following PRISMA guidelines.
  • Data extraction protocol and comprehensive search of multiple online databases.
  • Registered protocol (PROSPERO: CRD42023428460) ensuring methodological rigor.

Main Results:

  • Eight studies were included, demonstrating that miRNAs significantly reduce PrCa proliferation (OR=0.28, RR=0.51).
  • Moderate heterogeneity was observed for proliferation data (I²=57%).
  • MiRNAs showed significant predictive value for metastasis (OR=0.60, RR=0.72) with low heterogeneity (I²=0%).

Conclusions:

  • MiRNAs exhibit a clear effect on prostate cancer proliferation.
  • MiRNAs hold potential as reliable biomarkers for predicting PrCa metastasis.
  • Further investigation is warranted to elucidate the multifaceted roles of miRNAs in various aspects of PrCa.
Keywords:
biomarkergene polymorphismmetastasismicroRNAprostate cancer

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