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Updated: May 26, 2025
LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles
Published on: February 1, 2020
Molecular insight into histone methylation as a novel target for oral squamous cell carcinoma: future hope in
Peramaiyan Rajendran1, Monisha Prasad2, Enas M Ali1
1Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Abstract:
Oral squamous cell carcinoma (OSCC) is the most prevalent type of malignant epithelial neoplasm that affects the oral cavity. It has been a significant health concern in many countries for a long time since it was usually treated with surgery, radiation, and/or chemotherapy. Drug resistance is the primary issue in patient populations and scientific research, which promotes OSCC tumour cell invasion and migration. Thus, identifying highly specific therapeutic targets could be the potential approach for more successful treatment of OSCC. It is still challenging to understand the genetic causes of oral carcinogenesis due to its highly varied clinic-pathological parameters. It is important to remember that signaling channels and complexes that affect chromatin accessibility control gene expression, which in turn affects cell development and differentiation. Histones undergo post-translational alteration to give this platform. Understanding the processes of gene regulation through histone methylation and its modifications could enhance the early detection, prognostic prediction, and therapy of OSCC. To be properly used as a therapeutic target, histone methylation in OSCC requires more investigation. This review details the dysregulated histone methylation and the modifying enzymes linked to the development and aetiology of OSCC. Furthermore, the part that lysine methylation plays in cell migration, chemo-resistance, and OSCC invasion is also investigated.
Insights
Histone methylation, a key regulator of gene expression, is crucial for understanding oral squamous cell carcinoma (OSCC). Further research into histone methylation targets may improve OSCC treatment and prognosis.
Area of Science:
- Oncology
- Molecular Biology
- Epigenetics
Background:
- Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with significant treatment challenges, including drug resistance, invasion, and migration.
- Understanding the genetic and epigenetic factors driving oral carcinogenesis is complex due to varied clinic-pathological parameters.
- Histone modifications, particularly methylation, play a critical role in regulating gene expression, cell development, and differentiation.
Purpose of the Study:
- To review the dysregulated histone methylation patterns and associated enzymes in oral squamous cell carcinoma (OSCC).
- To investigate the role of lysine methylation in OSCC cell migration, chemo-resistance, and invasion.
- To highlight the potential of histone methylation as a therapeutic target for OSCC.
Main Methods:
- Literature review focusing on histone methylation and its modifying enzymes in the context of OSCC.
- Analysis of existing research on the impact of histone methylation on gene regulation, cell processes, and therapeutic resistance in OSCC.
- Examination of the specific role of lysine methylation in OSCC progression and invasion.
Main Results:
- Dysregulated histone methylation and its modifying enzymes are linked to the development and etiology of OSCC.
- Histone methylation significantly influences gene expression, affecting cell development and differentiation in oral cancer.
- Lysine methylation is implicated in promoting OSCC cell migration, invasion, and chemo-resistance.
Conclusions:
- Histone methylation is a critical epigenetic mechanism involved in OSCC pathogenesis.
- Targeting histone methylation pathways presents a promising strategy for improving early detection, prognostic prediction, and therapeutic outcomes in OSCC.
- Further investigation into histone methylation as a therapeutic target is warranted for effective OSCC treatment.
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