Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

830
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
830

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visible Light-Induced Intermolecular Dearomatization for Constructing Angularly Fused Tetracyclic Scaffolds.

Nature communications·2026
Same author

Dynamic Biomass-Based Hydrogel with Dual pH/Glucose Responsiveness for Controlled Nitric Oxide Release and Diabetic Wound Healing.

Biomacromolecules·2026
Same author

A Dual-Viral Delivery Platform Enables Efficient Site-Specific Integration of Therapeutic-Length Genes in Human Primary Stem Cells.

Human gene therapy·2026
Same author

Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC).

British journal of pharmacology·2026
Same author

The astrocytes in the prefrontal cortex contribute to the rapid antidepressant-like effects of psilocybin in the chronic restraint stress mouse model.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Organic Electrochemical Cathodic Reduction of CO, CN, and NN.

Chemical record (New York, N.Y.)·2026

Related Experiment Video

Updated: May 26, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.0K

Interleukin-33: A Double-Edged Sword in Sepsis.

Shuai Liu1, Yinyan Yue1, Qiuge Wu1

  • 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Translational Perioperative and Pain Medicine
|February 24, 2025
PubMed
Summary

Interleukin-33 (IL-33) plays a dual role in sepsis, aiding bacterial clearance and survival while also potentially worsening inflammation and organ damage. Understanding this complex immune response is crucial for improving sepsis outcomes.

Keywords:
Anti-inflammatoryInterleukin-33 (IL-33)Pro-inflammatorySepsis

More Related Videos

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

9.8K
Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.4K

Related Experiment Videos

Last Updated: May 26, 2025

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.0K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

9.8K
Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.4K

Area of Science:

  • Immunology
  • Sepsis Pathogenesis
  • Cytokine Biology

Background:

  • Sepsis remains a leading cause of mortality despite clinical advances.
  • The precise mechanisms of systemic inflammation and organ damage in sepsis are not fully elucidated.
  • Interleukin-33 (IL-33), a member of the IL-1 superfamily, exhibits dual cytokine and nuclear factor functions.

Purpose of the Study:

  • To review the current understanding of IL-33's multifaceted role in the host immune response to sepsis.
  • To highlight the "double-edged sword" nature of IL-33 in sepsis pathogenesis.
  • To synthesize updated information on IL-33's impact on inflammation, immunosuppression, and organ damage.

Main Methods:

  • Literature review of studies investigating IL-33 in sepsis models and patients.
  • Analysis of IL-33's functions as both a pro-inflammatory cytokine and a regulator of gene transcription.
  • Examination of IL-33's effects on immune cell modulation and organ injury in sepsis.

Main Results:

  • IL-33 demonstrates a dichotomous effect in sepsis, contributing to bacterial clearance and improved survival.
  • Conversely, IL-33 can exacerbate inflammation, induce immunosuppression, and promote organ damage.
  • The net effect of IL-33 in sepsis is dependent on the timing, context, and specific immune pathways involved.

Conclusions:

  • IL-33's dual role presents a complex therapeutic challenge in managing sepsis.
  • Further research is needed to precisely define IL-33's contribution to sepsis outcomes.
  • Targeting IL-33 pathways may offer novel strategies for sepsis treatment, but requires careful consideration of its opposing functions.