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Related Experiment Videos

Triamterene calculus.

E S Dickstein, W D Loeser

    The Journal of Urology
    |June 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Triamterene therapy can rarely cause kidney stones. This case involved a renal calculus predominantly composed of triamterene and its metabolites, highlighting an unusual presentation of drug-induced nephrolithiasis.

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    Area of Science:

    • Nephrology
    • Pharmacology
    • Urology

    Background:

    • Nephrolithiasis is a complex condition with various etiologies.
    • Triamterene is a potassium-sparing diuretic used in managing hypertension and edema.
    • Drug-induced nephrolithiasis is an uncommon but recognized complication of certain medications.

    Observation:

    • A case report of a patient presenting with a renal calculus.
    • The calculus was found to be predominantly composed of triamterene.
    • Significant amounts of triamterene's major metabolites were also identified within the stone.

    Findings:

    • Triamterene and its metabolites can form the primary component of a renal calculus.
    • This contrasts with the generally minor deposition of triamterene in previously reported stones.

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  • The formation of a triamterene-predominant stone suggests specific conditions favoring its precipitation.

    • Implications:

    • This case expands the understanding of triamterene's role in nephrolithiasis.
    • It underscores the importance of considering medication as a cause of kidney stones.
    • Further investigation into the mechanisms of triamterene calculus formation may be warranted.