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Updated: May 26, 2025
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Gold-Catalyzed 1,2-Carboxyarylation of Alkenes
Tanmayee Nanda1, Avishek Das1, Prafulla Bera1
1Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri 462 066, India.
Abstract:
Herein, we disclose an unprecedented gold-catalyzed 1,2-carboxyarylation of alkenes through ligand-enabled Au(I)/Au(III) catalysis. Unlike other approaches for the arylative functionalization of C-C multiple bonds, attempts to utilize weak nucleophiles such as carboxylate anions were unsuccessful. The key to achieving this transformation is the use of a 1,3-diketone-appended alkene, which undergoes gold-catalyzed oxyarylation followed by retro-aldol reaction to afford the product. Detailed mechanistic investigations were conducted to support the proposed mechanism.
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