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Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1

Miya B Hugaboom1, Lena V Wirth1, Kelly Street2

  • 1Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut.

Cancer Discovery
|February 24, 2025
PubMed
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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