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Related Experiment Video

Updated: May 26, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Lasmiditan and Different Triptans in Menstrual Migraine: A Bayesian Network Meta-analysis.

Zhaoming Song¹, Yanao Guo¹, Jingyu Gu¹

¹Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu Province, China.

Pain and Therapy

|February 24, 2025

Summary

Lasmiditan shows promise for treating menstrual migraine (MM), demonstrating superior sustained pain freedom compared to rizatriptan. Further research is needed to fully assess lasmiditan

Keywords:

Lasmiditan Menstrual migraine Meta-analysis Triptans

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Area of Science:

Neurology
Pharmacology
Clinical Trials

Background:

Menstrual migraine (MM) significantly impacts women's quality of life.
Current treatments for MM lack definitive evidence of superior efficacy.
Identifying effective MM therapies is crucial for patient well-being.

Purpose of the Study:

To compare the efficacy and safety of various drugs for menstrual migraine (MM).
To conduct a network meta-analysis of randomized controlled trials (RCTs) for MM treatments.
To evaluate treatments based on sustained pain freedom, 2-hour pain-free rates, and pain relief.

Main Methods:

Systematic search of PubMed, Embase, and Cochrane Library for RCTs up to December 2023.
Construction of a Bayesian network meta-analysis model to synthesize evidence.
Analysis of odds ratios (OR) and 95% confidence intervals (CI) for treatment comparisons.

Main Results:

Lasmiditan demonstrated a significantly higher rate of sustained freedom from pain compared to placebo (OR, 14; 95% CI 3.1-100).
No significant differences were observed between lasmiditan and triptans for 2-hour pain-free or pain relief rates.
Rizatriptan showed a statistically significant higher probability of adverse events compared to placebo (OR, 2.7; 95% CI 1.1-7.3).

Conclusions:

Lasmiditan is comparable to or better than some triptans for sustained pain freedom in MM treatment.
Lasmiditan presents a promising emerging therapeutic option for managing menstrual migraine.
Further safety analyses are required for lasmiditan due to limited data.