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Unilateral best vitelliform macular dystrophy- a case series
Dhanashree Ratra1, Abhishek Karra2
1Department of Vitreoretinal Diseases, Sankara Nethralaya, 41/18, College Road, Chennai, Tamil Nadu, 600006, India. dhanashreeratra@gmail.com.
Documenta Ophthalmologica. Advances in Ophthalmology
|February 24, 2025
Summary
Unilateral Best vitelliform macular dystrophy (VMD) can mimic other conditions. Multimodal imaging and electrooculography (EOG) are crucial for diagnosing this rare presentation of VMD.
Area of Science:
- Ophthalmology
- Medical Imaging
- Genetics
Background:
- Best vitelliform macular dystrophy (VMD) is typically a bilateral condition.
- Unilateral presentations of VMD are rare and can be misdiagnosed.
Purpose of the Study:
- To report two cases of unilateral Best vitelliform macular dystrophy (VMD).
- To describe multimodal imaging and electrooculography (EOG) findings in these cases.
Main Methods:
- Two patients with suspected central serous chorioretinopathy (CSCR) underwent detailed evaluation.
- Multimodal imaging (including optical coherence tomography and angiography) and EOG were performed.
Main Results:
- Both patients presented with unilateral macular neurosensory elevation and reduced vision.
- Optical coherence tomography revealed subretinal hyperreflective material and photoreceptor thinning.
- EOG confirmed the diagnosis by showing a reduced light peak to dark trough (LP:DT) ratio, despite normal fluorescein and indocyanine green angiography findings.
Conclusions:
- Unilateral VMD is a rare but possible clinical presentation.
- Multimodal imaging and EOG are essential for differentiating unilateral VMD from CSCR.
- EOG, alongside genetic testing, can confirm the diagnosis of Best VMD.
