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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Updated: May 26, 2025

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

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Circulating Tumor Microenvironment in Metastasis.

Rui Tang1, Shujuan Luo2, Hui Liu3

  • 1Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.

Cancer Research
|February 24, 2025
PubMed
Summary
This summary is machine-generated.

The circulating tumor microenvironment (cTME) significantly impacts cancer metastasis, influencing circulating tumor cell (CTC) survival and spread. Understanding the cTME offers new therapeutic targets and biomarkers for cancer treatment.

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Area of Science:

  • Oncology
  • Cell Biology
  • Biophysics

Background:

  • Cancer metastasis is the primary cause of cancer-related death.
  • Circulating tumor cells (CTCs) face numerous challenges during metastasis.
  • The circulating tumor microenvironment (cTME) profoundly influences CTC fate.

Purpose of the Study:

  • To review recent advancements in understanding the cTME.
  • To highlight the role of biophysical cues and components within the cTME.
  • To explore the cTME's potential as a therapeutic target and biomarker.

Main Methods:

  • Literature review of recent studies on the cTME.
  • Analysis of biophysical cues, cellular, and non-cellular components of the cTME.
  • Synthesis of information on the biological roles and network interactions within the cTME.

Main Results:

  • The cTME is a dynamic liquid microenvironment distinct from primary or pre-metastatic niches.
  • Biophysical attributes, blood cells, and non-blood factors interact within the cTME.
  • Specific components and cues within the cTME influence CTC survival and metastasis.

Conclusions:

  • The cTME plays a critical role in regulating cancer metastasis.
  • Targeting the cTME presents a promising strategy for inhibiting metastasis.
  • The cTME holds potential as a biomarker for predicting patient outcomes.