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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: May 26, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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Photothermal-Therapy-Based Targeting Thrombolytic Therapy.

Chi Zhang1,2, Xianfeng Chen1,2

  • 1Department of Intensive Care Unit, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, P. R. China.

ACS Applied Bio Materials
|February 24, 2025
PubMed
Summary

Advanced photothermal nanomaterials offer a promising solution for treating thrombosis, enhancing drug delivery and minimizing bleeding risks associated with traditional therapies.

Keywords:
antithrombotic drugsnear-infrared lightphotothermal nanomaterialsphotothermal therapytargeted deliverythrombolysis

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Thrombosis is a leading cause of death, with current treatments having limitations like bleeding risks and poor targeting.
  • Photothermal therapy (PTT) shows promise for thrombus treatment due to its precision and minimal invasiveness.
  • Conventional PTT faces challenges in light penetration depth and photothermal agent efficiency.

Purpose of the Study:

  • To review recent advancements in photothermal nanomaterials for thrombus treatment.
  • To highlight composite nanomaterials and targeted modification strategies.
  • To discuss combined therapeutic approaches for enhanced antithrombotic therapy.

Main Methods:

  • Focus on near-infrared (NIR)-mediated photothermal conversion nanomaterials.
  • Exploration of composite nanocarriers with multiple components.
  • Investigation of targeting ligand modifications and biomimetic strategies.

Main Results:

  • NIR-mediated nanomaterials enhance photothermal thrombolysis through deeper tissue penetration and efficient heat conversion.
  • Nanomaterial modification allows targeted drug delivery to thrombi, improving therapeutic specificity.
  • Combined approaches, including drug loading and photodynamic therapy, show potential for comprehensive thrombus management.

Conclusions:

  • Photothermal nanomaterials, particularly NIR-mediated ones, offer a superior alternative for treating thrombotic diseases.
  • Targeted modifications and composite designs are key to optimizing nanomaterial performance.
  • Integrated therapeutic strategies hold significant promise for effective and safer thrombus management.